GGT hydrolyses PCTR2 to PCTR3

Stable Identifier
R-HSA-9026907
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In human macrophages, protectin conjugate in tissue regeneration 3 (PCTR2) is proposed to be hydrolysed to PCTR3 (16-cysteinyl, 17-hydroxy-docosahexaenoic acid) by the actions of a glutathione transferase (GGT). Human macrophages incubated with E. coli and a GGT inhibitor led to increased levels of PCTR1 and decreased levels of PCTR3, suggesting a role for GGT enzyme in PCTR2 and PCTR3 biosynthesis (Dalli et al. 2015).

Literature References
PubMed ID Title Journal Year
25713027 Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

Dalli, J, Ramon, S, Norris, PC, Colas, RA, Serhan, CN

FASEB J. 2015
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Catalyst Activity
Catalyst Activity
Title
glutathione hydrolase activity of GGT [cytosol]
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Activity
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