GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1

Stable Identifier
R-HSA-9026901
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1
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Human macrophages produce protectin conjugates in tissue regeneration (PCTR). PCTR are named as such because they share a proposed biosynthetic pathway, structural features, and biological actions with DHA-derived protectins as well as displaying potent tissue-regenerative actions. 16S,17S-epoxy-docosahexaenoic acid (16S,17S-epoxy-DHA) was found to be a substrate for a glutathione transferase (GGT) which produces PCTR1 (16-glutathionyl, 17-hydroxy-docosahexaenoic acid) in greater quantities in M2-type macrophages than M1-type macrophages and was found to enhance resolution of infectious inflammation (Ramon et al. 2016, Dalli et al. 2015).
Literature References
PubMed ID Title Journal Year
25713027 Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

Dalli, J, Ramon, S, Norris, PC, Colas, RA, Serhan, CN

FASEB J. 2015
26878209 The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation

Ramon, S, Dalli, J, Sanger, JM, Winkler, JW, Aursnes, M, Tungen, JE, Hansen, TV, Serhan, CN

Am. J. Pathol. 2016
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glutathione transferase activity of GGT [cytosol]

Physical Entity
GGT [cytosol] (Homo sapiens)
Activity
glutathione transferase activity (GO:0004364)
Authored
Jassal, B  (2017-10-24)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-24)
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