GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Human macrophages produce protectin conjugates in tissue regeneration (PCTR). PCTR are named as such because they share a proposed biosynthetic pathway, structural features, and biological actions with DHA-derived protectins as well as displaying potent tissue-regenerative actions. 16S,17S-epoxy-docosahexaenoic acid (16S,17S-epoxy-DHA) was found to be a substrate for a glutathione transferase (GGT) which produces PCTR1 (16-glutathionyl, 17-hydroxy-docosahexaenoic acid) in greater quantities in M2-type macrophages than M1-type macrophages and was found to enhance resolution of infectious inflammation (Ramon et al. 2016, Dalli et al. 2015).

Literature References
PubMed ID Title Journal Year
25713027 Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

Norris, PC, Serhan, CN, Colas, RA, Ramon, S, Dalli, J

FASEB J. 2015
26878209 The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation

Serhan, CN, Winkler, JW, Sanger, JM, Hansen, TV, Tungen, JE, Aursnes, M, Dalli, J, Ramon, S

Am. J. Pathol. 2016
Catalyst Activity

glutathione transferase activity of GGT [cytosol]

Cite Us!