ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4

Stable Identifier
R-HSA-9026405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4
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In neutrophils, 5-lipoxygenase (ALOX5) oxidises 13(R)-hydroxy-docosapentaenoic acid (13(R)-DPAn-3) to the 13(R)-resolvins RvT1-4 (7,13,20-trihydroxy-docosapentaenoic acid, 7,12,13-trihydroxy-docosapentaenoic acid, 7,8,13-trihydroxy-docosapentaenoic acid and 7,13-dihydroxy-docosapentaenoic acid respectively) (Dalli et al. 2015, Primdahl et al. 2016). They were all shown to posses anti-inflammatory and proresolving activities (Dalli et al. 2015). Recently, RvTs have been shown to mediate the proresolving actions of several statins in mice with inflammatory arthritis (Walker et al. 2017).
Literature References
PubMed ID Title Journal Year
26236990 Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

Serhan, CN, Chiang, N, Dalli, J

Nat. Med. 2015
27704804 Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins

Serhan, CN, Colas, RA, Primdahl, KG, Hansen, TV, Aursnes, M, Walker, ME, Vik, A, Dalli, J

J. Nat. Prod. 2016
Participants
Input
Output
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as an event of
Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]

Physical Entity
ALOX5 [cytosol] (Homo sapiens)
Activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen (GO:0016701)
Orthologous Events
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Bos taurus)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Canis familiaris)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Danio rerio)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Dictyostelium discoideum)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Gallus gallus)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Mus musculus)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Rattus norvegicus)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Sus scrofa)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Xenopus tropicalis)
Authored
Jassal, B  (2017-10-19)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-19)
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