Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA

Stable Identifier
R-HSA-9026008
Type
Reaction [transition]
Species
Homo sapiens
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In neutrophils, an epoxide hydrolase is thought to hydrolyse 7,8-epoxy-17-hydroxydocosapentaenoic acid (7,8-epoxy-HDPAn-3) to either of the resolvins 7,8,17-trihydroxy-docosapentaenoic acid (RvD1n-3DPA) or 7,16,17-trihydroxy-docosapentaenoic acid (RvD2n-3DPA) (Dalli et al. 2013). Treatment of induced inflammation in mice with RvD1n-3DPA and RvD2n-3DPA reduced neutrophil infiltration and adhesion and enhanced macrophage phagocytosis; all key steps in inflammatory resolution (Dalli et al. 2013, Gobbetti et al. 2017). Although this is a proposed biosynthetic route for the formation of DPA-n-3 resolvins, it is assumed DPAn-3-derived SPMs follow a similar synthesis route to DHA- and EPA-derived SPMs.

Literature References
PubMed ID Title Journal Year
23736886 Novel n-3 immunoresolvents: structures and actions

Dalli, J, Colas, RA, Serhan, CN

Sci Rep 2013
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Catalyst Activity
Title
epoxide hydrolase activity of Epoxide hydrolase [cytosol]
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