ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3

Stable Identifier
R-HSA-9026006
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In a parallel pathway to 15-lipoxygenase-initiated protectin formation from ω-3 docosapentaenoic acid (DPAn-3), 12-lipoxygenase can also oxygenate DPAn-3 to form 14(S)-hydroperoxy-docosapentaenoic acid (14(S)-Hp-DPAn-3) (Dalli et al. 2013). This intermediate is the precursor for DPA-n-3-derived maresins.

Literature References
PubMed ID Title Journal Year
23736886 Novel n-3 immunoresolvents: structures and actions

Dalli, J, Colas, RA, Serhan, CN

Sci Rep 2013
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Catalyst Activity
Catalyst Activity
Title
arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]
Physical Entity
Activity
Orthologous Events
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