Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA

Stable Identifier
R-HSA-9026001
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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A hydroperoxy reductase probably reduces 7,17-dihydroperoxy-docosapentaenoic acid (7,17-diHp-DPAn-3) to the resolvin 7,17-dihydroxy-docosapentaenoic acid (RvD5n-3DPA) (Dalli et al. 2013). Treatment with RvD5n-3DPA reduced colitis and intestinal ischemia/reperfusion-induced inflammation in mice and reduced human neutrophil-endothelial cell interactions with TNF-α-activated human endothelial monolayers (Gobbetti et al. 2017). Although this is a proposed biosynthetic route for the formation of DPA-n-3 resolvins, it is assumed DPAn-3-derived SPMs follow a similar synthesis route to DHA- and EPA-derived SPMs.

Literature References
PubMed ID Title Journal Year
23736886 Novel n-3 immunoresolvents: structures and actions

Dalli, J, Colas, RA, Serhan, CN

Sci Rep 2013
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Catalyst Activity
Title
oxidoreductase activity of Hydroperoxy reductase [cytosol]
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