In neutrophils, an epoxide hydrolase can hydrolyse 16(S),17(S)-epoxy-docosapentaenoic acid (16(S),17(S)-epoxy-DPAn-3) to either 10(R),17(S)-dihydroxy-docosapentaenoic acid (PD1n-3DPA) or 16,17(S)-dihydroxy-docosapentaenoic acid (PD2n-3DPA) (Dalli et al. 2013). The formation of these protectins is supported by chemical synthesis experiments (Aursnes et al. 2014, Primdahl et al. 2017). These DPAn-3-derived protectins demonstrate potent anti-inflammatory activities together with pro-resolving actions, stimulating human macrophage phagocytosis and efferocytosis (Dalli et al. 2013, Aursnes et al. 2014, Primdahl et al. 2017, Gobbetti et al. 2017).