In neutrophils, an unknown lipoxygenase may mediate hydrogen abstraction from 17(S)-hydroperoxy-docosapentaenoic acid (17(S)-Hp-DPAn-3) to form 16(S),17(S)-epoxy-docosapentaenoic acid (16(S),17(S)-epoxy-DPAn-3) (Dalli et al. 2013). If, as assumed, DPA metabolism follows the same path as DHA metabolism, the lipoxygenase could be the dual-functional 5-lipoxygenase (ALOX5). The formation of this epoxy intermediate is supported by chemical synthesis experiments (Aursnes et al. 2014, Primdahl et al. 2017).
Aursnes, M, Tungen, JE, Vik, A, Colas, RA, Cheng, CY, Dalli, J, Serhan, CN, Hansen, TV
Dalli, J, Colas, RA, Serhan, CN
Primdahl, KG, Tungen, JE, De Souza, PRS, Colas, RA, Dalli, J, Hansen, TV, Vik, A
arachidonate 5-lipoxygenase activity of ALOX5 [cytosol]
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