Reactome | IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5

IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5

Stable Identifier

R-HSA-9025969

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5

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Signal transducer and activator of transcription 5A/B (STAT5A and/or STAT5B, typically referred to as STAT5) are believed to bind tyrosine-phosphorylated IL7R. Several studies have demonstrated STAT5 phosphorylation following Interleukin‑7 (IL7) ligand‑receptor interaction (Foxwell et al. 1995, van der Plas et al. 1996, Yu et al. 1998, Jufrroy et al. 2010, Landires et al. 2011).

STAT5 is activated in COS7 cells when co‑transfected with JAK3 (Lin et al. 1996), though this does not demonstrate that JAK3 is responsible for STAT5 phosphorylation in vivo (Lin & Leonard, 2000). STAT5 binding is represented here as a black box event as it is inferred to be a prerequisite of IL7-induced STAT5 phosphorylation.

Literature References

PubMed ID	Title	Journal	Year
8709637	Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain van der Plas, DC, Smiers, F, Pouwels, K, Hoefsloot, LH, Löwenberg, B, Touw, IP	Leukemia	1996
7489741	Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells Foxwell, BM, Beadling, C, Guschin, D, Kerr, I, Cantrell, D	Eur J Immunol	1995