IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5

Stable Identifier
R-HSA-9025969
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Signal transducer and activator of transcription 5A/B (STAT5A and/or STAT5B, typically referred to as STAT5) are believed to bind tyrosine-phosphorylated IL7R. Several studies have demonstrated STAT5 phosphorylation following Interleukin‑7 (IL7) ligand‑receptor interaction (Foxwell et al. 1995, van der Plas et al. 1996, Yu et al. 1998, Jufrroy et al. 2010, Landires et al. 2011).

STAT5 is activated in COS7 cells when co‑transfected with JAK3 (Lin et al. 1996), though this does not demonstrate that JAK3 is responsible for STAT5 phosphorylation in vivo (Lin & Leonard, 2000). STAT5 binding is represented here as a black box event as it is inferred to be a prerequisite of IL7-induced STAT5 phosphorylation.

Literature References
PubMed ID Title Journal Year
7489741 Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

Foxwell, BM, Beadling, C, Guschin, D, Kerr, I, Cantrell, D

Eur J Immunol 1995
8709637 Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain

van der Plas, DC, Smiers, F, Pouwels, K, Hoefsloot, LH, Löwenberg, B, Touw, IP

Leukemia 1996
Participants
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Orthologous Events
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