Reactome | ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6

ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6

Stable Identifier

R-HSA-9025957

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6

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The main product of ω-6 docosapentaenoic acid (DPAn-6) oxygenation by 12-lipoxygenase (ALOX12:Fe2+) is 14(S)-hydroxy-DPAn-6 (14(S)-HDPAn-6) (Dangi et al. 2009, 2010, Dobson et al. 2013). The final product is produced via a hydroperoxy intermediate, which is then reduced to the corresponding hydroxy compound (these details not described here and also, the human enzymes involved in these reactions are unknown). This DPAn-6 product is analogous in structure and action to DHA (docosahexaenoic acid)-derived resolvins (Dangi et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
23471029	Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase Kralovec, JA, Dobson, EP, Adcock, JL, Barrow, CJ	J. Lipid Res.	2013
19679107	Metabolism and biological production of resolvins derived from docosapentaenoic acid (DPAn-6) Arterburn, LM, Hallenbeck, T, Chung, G, Nauroth, JM, Obeng, M, Dangi, B, Bailey-Hall, E	Biochem. Pharmacol.	2010
19324874	Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6) Needham, M, Arterburn, LM, Nauroth, JM, Teymourlouei, M, Obeng, M, Raman, K, Dangi, B	J. Biol. Chem.	2009