ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The main product of ω-6 docosapentaenoic acid (DPAn-6) oxygenation by 12-lipoxygenase (ALOX12:Fe2+) is 14(S)-hydroxy-DPAn-6 (14(S)-HDPAn-6) (Dangi et al. 2009, 2010, Dobson et al. 2013). The final product is produced via a hydroperoxy intermediate, which is then reduced to the corresponding hydroxy compound (these details not described here and also, the human enzymes involved in these reactions are unknown). This DPAn-6 product is analogous in structure and action to DHA (docosahexaenoic acid)-derived resolvins (Dangi et al. 2010).

Literature References
PubMed ID Title Journal Year
23471029 Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase

Kralovec, JA, Dobson, EP, Adcock, JL, Barrow, CJ

J. Lipid Res. 2013
19679107 Metabolism and biological production of resolvins derived from docosapentaenoic acid (DPAn-6)

Arterburn, LM, Hallenbeck, T, Chung, G, Nauroth, JM, Obeng, M, Dangi, B, Bailey-Hall, E

Biochem. Pharmacol. 2010
19324874 Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6)

Needham, M, Arterburn, LM, Nauroth, JM, Teymourlouei, M, Obeng, M, Raman, K, Dangi, B

J. Biol. Chem. 2009
Catalyst Activity

arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]

Orthologous Events
Cite Us!