Reactome | ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6

ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6

Stable Identifier

R-HSA-9025957

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The main product of ω-6 docosapentaenoic acid (DPAn-6) oxygenation by 12-lipoxygenase (ALOX12:Fe2+) is 14(S)-hydroxy-DPAn-6 (14(S)-HDPAn-6) (Dangi et al. 2009, 2010, Dobson et al. 2013). The final product is produced via a hydroperoxy intermediate, which is then reduced to the corresponding hydroxy compound (these details not described here and also, the human enzymes involved in these reactions are unknown). This DPAn-6 product is analogous in structure and action to DHA (docosahexaenoic acid)-derived resolvins (Dangi et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
23471029	Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase Dobson, EP, Barrow, CJ, Kralovec, JA, Adcock, JL	J. Lipid Res.	2013
19679107	Metabolism and biological production of resolvins derived from docosapentaenoic acid (DPAn-6) Dangi, B, Obeng, M, Nauroth, JM, Chung, G, Bailey-Hall, E, Hallenbeck, T, Arterburn, LM	Biochem. Pharmacol.	2010
19324874	Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6) Dangi, B, Obeng, M, Nauroth, JM, Teymourlouei, M, Needham, M, Raman, K, Arterburn, LM	J. Biol. Chem.	2009