Biosynthesis of DPAn-6 SPMs

Stable Identifier
R-HSA-9025106
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Biosynthesis of DPAn-6 SPMs
Click the image above or here to open this pathway in the Pathway Browser

The biosynthesis of specialised proresolving mediators (SPMs) derived from the ω-6 isomer of DPA, DPAn-6 (cis-4,7,10,13,16-docosapentaenoic acid) is described here (Dangi et al. 2010). The products of the ω-6 isomer were characterised by analogy in structure and action to docosahexaenoic acid (DHA)-derived and eicosapentaenoic acid (EPA)-derived resolvins (Serhan et al. 2002, Bannenberg & Serhan 2010).

Literature References
PubMed ID Title Journal Year
19679107 Metabolism and biological production of resolvins derived from docosapentaenoic acid (DPAn-6)

Dangi, B, Obeng, M, Nauroth, JM, Chung, G, Bailey-Hall, E, Hallenbeck, T, Arterburn, LM

Biochem. Pharmacol. 2010
26546723 Docosapentaenoic acid derived metabolites and mediators - The new world of lipid mediator medicine in a nutshell

Weylandt, KH

Eur. J. Pharmacol. 2016
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
long-chain fatty acid biosynthetic process (0042759)
Orthologous Events
Biosynthesis of DPAn-6 SPMs (Bos taurus)
Biosynthesis of DPAn-6 SPMs (Canis familiaris)
Biosynthesis of DPAn-6 SPMs (Danio rerio)
Biosynthesis of DPAn-6 SPMs (Dictyostelium discoideum)
Biosynthesis of DPAn-6 SPMs (Mus musculus)
Biosynthesis of DPAn-6 SPMs (Rattus norvegicus)
Biosynthesis of DPAn-6 SPMs (Sus scrofa)
Cross References
BioModels Database
Authored
Jassal, B  (2017-10-12)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-12)