Neurotrophin receptor tyrosine kinase NTRK2 (TRKB) is a low affinity receptor for neurotrophin-3 (NTF3, also known as NT-3) (Soppet et al. 1991). NTF3 predominantly functions as the ligand for the NTRK3 (TRKC) receptor (Marsh and Palfrey 1996). Binding to NTF3 can trigger NTRK2 dimerization (Ohira et al. 2001) and trans-autophosphorylation of NTRK2 dimers on conserved tyrosine residues in the cytoplasmic tail of the receptor (Middlemas et al. 1994). The efficacy of this process, however, is low in comparison to NTRK2 activation by BDNF and NTF3, and downstream signaling has not been studied.
Hayashi, M, Ohira, K, Shimizu, K
Marsh, HN, Palfrey, HC
Parada, LF, Middlemas, DS, Maragos, J, Soppet, D, Escandon, E, Burton, LE, Hunter, T, Stanton, BR, Nikolics, K, Blair, J, Kaplan, DR, Reid, SW
Middlemas, DS, Hunter, T, Meisenhelder, J
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