NTF3 activates NTRK2 (TRKB) signaling

Stable Identifier
R-HSA-9025046
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Pathway
Species
Homo sapiens
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Neurotrophin receptor tyrosine kinase NTRK2 (TRKB) is a low affinity receptor for neurotrophin-3 (NTF3, also known as NT-3) (Soppet et al. 1991). NTF3 predominantly functions as the ligand for the NTRK3 (TRKC) receptor (Marsh and Palfrey 1996). Binding to NTF3 can trigger NTRK2 dimerization (Ohira et al. 2001) and trans-autophosphorylation of NTRK2 dimers on conserved tyrosine residues in the cytoplasmic tail of the receptor (Middlemas et al. 1994). The efficacy of this process, however, is low in comparison to NTRK2 activation by BDNF and NTF3, and downstream signaling has not been studied.

Literature References
PubMed ID Title Journal Year
8752100 Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons

Marsh, HN, Palfrey, HC

J. Neurochem. 1996
11536331 TrkB dimerization during development of the prefrontal cortex of the macaque

Ohira, K, Shimizu, K, Hayashi, M

J. Neurosci. Res. 2001
1645620 The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

Soppet, D, Escandon, E, Maragos, J, Middlemas, DS, Reid, SW, Blair, J, Burton, LE, Stanton, BR, Kaplan, DR, Hunter, T, Nikolics, K, Parada, LF

Cell 1991
8106527 Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor

Middlemas, DS, Meisenhelder, J, Hunter, T

J. Biol. Chem. 1994
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