Reactome | ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA

ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA

Stable Identifier

R-HSA-9024997

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA

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In macrophages, lipoxygenase 5 (ALOX5) is proposed to further oxygenate 14(S)-hydroperoxy-docosahexaenoic acid (14(S)-Hp-DHA) to 7(S),14(S)-dihydroperoxy-docosaheaenoic acid (7(S),14(S)-diHp-DHA) (Serhan et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19103881	Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions Kasuga, K, Pillai, PS, Serhan, CN, Spite, M, Oh, SF, Porter, TF, Martinod, K, Yang, R	J. Exp. Med.	2009