ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA

Stable Identifier
R-HSA-9024997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA
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In macrophages, lipoxygenase 5 (ALOX5) is proposed to further oxygenate 14(S)-hydroperoxy-docosahexaenoic acid (14(S)-Hp-DHA) to 7(S),14(S)-dihydroperoxy-docosaheaenoic acid (7(S),14(S)-diHp-DHA) (Serhan et al. 2009).
Literature References
PubMed ID Title Journal Year
19103881 Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

Kasuga, K, Pillai, PS, Serhan, CN, Spite, M, Oh, SF, Porter, TF, Martinod, K, Yang, R

J. Exp. Med. 2009
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Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]

Physical Entity
ALOX5 [cytosol] (Homo sapiens)
Activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen (GO:0016701)
Orthologous Events
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Bos taurus)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Canis familiaris)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Danio rerio)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Dictyostelium discoideum)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Gallus gallus)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Mus musculus)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Rattus norvegicus)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Sus scrofa)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Xenopus tropicalis)
Authored
Jassal, B  (2017-10-11)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-11)
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