Reactome | LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1

LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1

Stable Identifier

R-HSA-9024890

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1

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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). When produced in neural tissue, where it affords potent tissue protective actions, this docsanoid is called neuroprotectin D1 (NPD1).

Literature References

PubMed ID	Title	Journal	Year
16424216	Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes Lu, Y, Serhan, CN, Colgan, SP, Petasis, NA, Hong, S, Baer, T, Yang, R, Gotlinger, K, Siegelman, J	J. Immunol.	2006
12590139	Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation Serhan, CN, Gronert, K, Devchand, PR, Hong, S, Moussignac, RL	J. Biol. Chem.	2003