LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1

Stable Identifier
R-HSA-9024890
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). When produced in neural tissue, where it affords potent tissue protective actions, this docsanoid is called neuroprotectin D1 (NPD1).

Literature References
PubMed ID Title Journal Year
12590139 Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation

Hong, S, Gronert, K, Devchand, PR, Moussignac, RL, Serhan, CN

J. Biol. Chem. 2003
16424216 Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes

Serhan, CN, Gotlinger, K, Hong, S, Lu, Y, Siegelman, J, Baer, T, Yang, R, Colgan, SP, Petasis, NA

J. Immunol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
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