EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1

Stable Identifier
R-HSA-9024723
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
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CRKL, in a constitutive complex with RAPGEF1 (C3G, a nucleotide exchange factor for RAP1), binds the cytoplasmic domain of EPOR in the region of phosphotyrosine-460 (Arai et al. 2001).
Literature References
PubMed ID Title Journal Year
11124936 Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion

Arai, A, Nosaka, Y, Kanda, E, Yamamoto, K, Miyasaka, N, Miura, O

J. Biol. Chem. 2001
11443118 CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling

Arai, A, Kanda, E, Nosaka, Y, Miyasaka, N, Miura, O

J. Biol. Chem. 2001
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Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Crkl:Rapgef1 (Mus musculus)
Authored
May, B  (2017-10-01)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-10-09)
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