Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5

Stable Identifier
R-HSA-9024630
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5
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An unknown reductase mediates the reduction of 7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid (7(S)-Hp-17(R)-HDHA) to AT-RvD5 (Serhan et al. 2002), the structure of which has been chemically synthesised as 7(S),17(R)-dihydroxydocosahexaenoic acid (Ogawa et al. 2017). In mice with E.coli infection, several specialized pro-resolving mediators (SPMs) including RvD5, together with antibiotics, accelerated resolution and heightened host antimicrobial responses (Chiang et al. 2012).
Literature References
PubMed ID Title Journal Year
12391014 Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

Gronert, K, Serhan, CN, Devchand, PR, Colgan, SP, Hong, S, Mirick, G, Moussignac, RL

J. Exp. Med. 2002
28098462 Total Synthesis of Resolvin D5

Morita, M, Suganuma, Y, Kobayashi, Y, Ogawa, N, Sugiyama, T

J. Org. Chem. 2017
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Catalyst Activity

oxidoreductase activity of Hydroperoxy reductase [cytosol]

Physical Entity
Hydroperoxy reductase [cytosol] (Homo sapiens)
Activity
oxidoreductase activity (GO:0016491)
Authored
Jassal, B  (2017-09-05)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-06)
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