Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5

Stable Identifier
R-HSA-9024630
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

An unknown reductase mediates the reduction of 7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid (7(S)-Hp-17(R)-HDHA) to AT-RvD5 (Serhan et al. 2002), the structure of which has been chemically synthesised as 7(S),17(R)-dihydroxydocosahexaenoic acid (Ogawa et al. 2017). In mice with E.coli infection, several specialized pro-resolving mediators (SPMs) including RvD5, together with antibiotics, accelerated resolution and heightened host antimicrobial responses (Chiang et al. 2012).

Literature References
PubMed ID Title Journal Year
28098462 Total Synthesis of Resolvin D5

Ogawa, N, Sugiyama, T, Morita, M, Suganuma, Y, Kobayashi, Y

J. Org. Chem. 2017
12391014 Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

Serhan, CN, Hong, S, Gronert, K, Colgan, SP, Devchand, PR, Mirick, G, Moussignac, RL

J. Exp. Med. 2002
Participants
Participates
Catalyst Activity

oxidoreductase activity of Hydroperoxy reductase [cytosol]

Authored
Reviewed
Created
Cite Us!