Reactome | HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1

HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1

Stable Identifier

R-HSA-9023968

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1

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In human blood, the major metabolic products of RvE1 are 10,11-dihydro-RvE1, 18-oxo-RvE1, and 20-hydroxy-RvE1 (Hong et al. 2008). 18-oxo-RvE1, formed by dimeric 15-hydroxyprostaglandin dehydrogenase (HPGD dimer) in the presence of NAD+, is also the major metabolite formed in murine lung and has been demonstrated to be devoid of activity, representing a mode of RvE1 inactivation (Arita et al. 2006). The exact enzymes that catalyze the formation of the other RvE1 metabolites mentioned here are currently unknown.

Literature References

PubMed ID	Title	Journal	Year
18292578	Resolvin E1 metabolome in local inactivation during inflammation-resolution Hong, S, Porter, TF, Lu, Y, Oh, SF, Pillai, PS, Serhan, CN	J. Immunol.	2008
16757471	Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions Arita, M, Oh, SF, Chonan, T, Hong, S, Elangovan, S, Sun, YP, Uddin, J, Petasis, NA, Serhan, CN	J. Biol. Chem.	2006