HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1

Stable Identifier
Reaction [transition]
Homo sapiens
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In human blood, the major metabolic products of RvE1 are 10,11-dihydro-RvE1, 18-oxo-RvE1, and 20-hydroxy-RvE1 (Hong et al. 2008). 18-oxo-RvE1, formed by dimeric 15-hydroxyprostaglandin dehydrogenase (HPGD dimer) in the presence of NAD+, is also the major metabolite formed in murine lung and has been demonstrated to be devoid of activity, representing a mode of RvE1 inactivation (Arita et al. 2006). The exact enzymes that catalyze the formation of the other RvE1 metabolites mentioned here are currently unknown.

Literature References
PubMed ID Title Journal Year
18292578 Resolvin E1 metabolome in local inactivation during inflammation-resolution

Pillai, PS, Serhan, CN, Lu, Y, Oh, SF, Porter, TF, Hong, S

J. Immunol. 2008
16757471 Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions

Serhan, CN, Arita, M, Oh, SF, Petasis, NA, Elangovan, S, Chonan, T, Hong, S, Uddin, J, Sun, YP

J. Biol. Chem. 2006
Catalyst Activity

15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]

Orthologous Events
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