HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1

Stable Identifier
R-HSA-9023968
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In human blood, the major metabolic products of RvE1 are 10,11-dihydro-RvE1, 18-oxo-RvE1, and 20-hydroxy-RvE1 (Hong et al. 2008). 18-oxo-RvE1, formed by dimeric 15-hydroxyprostaglandin dehydrogenase (HPGD dimer) in the presence of NAD+, is also the major metabolite formed in murine lung and has been demonstrated to be devoid of activity, representing a mode of RvE1 inactivation (Arita et al. 2006). The exact enzymes that catalyze the formation of the other RvE1 metabolites mentioned here are currently unknown.

Literature References
PubMed ID Title Journal Year
16757471 Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions

Arita, M, Oh, SF, Chonan, T, Hong, S, Elangovan, S, Sun, YP, Uddin, J, Petasis, NA, Serhan, CN

J. Biol. Chem. 2006
18292578 Resolvin E1 metabolome in local inactivation during inflammation-resolution

Hong, S, Porter, TF, Lu, Y, Oh, SF, Pillai, PS, Serhan, CN

J. Immunol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]
Physical Entity
Activity
Orthologous Events
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