Reactome | NCOA1 recruits EP300 to TGFA promoter

NCOA1 recruits EP300 to TGFA promoter

Stable Identifier

R-HSA-9023884

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Estrogen-dependent interaction between NCOA1 and EP300 recruits EP300 to the TGFA promoter (Halachmi et al, 1994; Cavaillès et al, 1994; Harnstein et al, 2001). NCOA1 and EP300 contribute to active chromatin structures through their coactivator and histone acetyltransferase activity (reviewed in Xu et al, 2007; Arnal et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
28539435	Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications Arnal, JF, Lenfant, F, Métivier, R, Flouriot, G, Henrion, D, Adlanmerini, M, Fontaine, C, Gourdy, P, Chambon, P, Katzenellenbogen, B, Katzenellenbogen, J	Physiol. Rev.	2017
7937828	Interaction of proteins with transcriptionally active estrogen receptors Cavaillès, V, Dauvois, S, Danielian, PS, Parker, MG	Proc. Natl. Acad. Sci. U.S.A.	1994
8197458	Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription Halachmi, S, Marden, E, Martin, G, MacKay, H, Abbondanza, C, Brown, M	Science	1994
14631847	Acetylation and methylation in nuclear receptor gene activation Xu, W, Cho, H, Evans, RM	Meth. Enzymol.	2003
8876171	p300 is a component of an estrogen receptor coactivator complex Hanstein, B, Eckner, R, DiRenzo, J, Halachmi, S, Liu, H, Searcy, B, Kurokawa, R, Brown, M	Proc. Natl. Acad. Sci. U.S.A.	1996