PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PRMT1 is an H4 R3 methyltransferase that is recruited to the TFF promoter where, in conjunction with acetyltransferases, it establishes transcriptionally active chromatin (Métivier et al, 2003. CARM1 is an alternate arginine methyltransferase with activity toward H3 R17 that acts at the TFF enhancer, however CARM1 and PRMT1 are never found simultaneously at the TFF1 gene (Métivier et al, 2003; reviewed in Xu et al, 2003; Arnal et al, 2017).Note that in this diagram, methylation of H4 R3 is not depicted.

Literature References
PubMed ID Title Journal Year
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Katzenellenbogen, B, Chambon, P, Flouriot, G, Métivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M

Physiol. Rev. 2017
14675539 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Hübner, MR

Cell 2003
14631847 Acetylation and methylation in nuclear receptor gene activation

Xu, W, Evans, RM, Cho, H

Meth. Enzymol. 2003
Orthologous Events
Cite Us!