PRMT1 is an H4 R3 methyltransferase that is recruited to the TFF promoter where, in conjunction with acetyltransferases, it establishes transcriptionally active chromatin (Métivier et al, 2003. CARM1 is an alternate arginine methyltransferase with activity toward H3 R17 that acts at the TFF enhancer, however CARM1 and PRMT1 are never found simultaneously at the TFF1 gene (Métivier et al, 2003; reviewed in Xu et al, 2003; Arnal et al, 2017).Note that in this diagram, methylation of H4 R3 is not depicted.
Katzenellenbogen, B, Chambon, P, Flouriot, G, Métivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M
Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Hübner, MR
Xu, W, Evans, RM, Cho, H
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