Reactome | PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene

PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene

Stable Identifier

R-HSA-9023861

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene

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PRMT1 is an H4 R3 methyltransferase that is recruited to the TFF promoter where, in conjunction with acetyltransferases, it establishes transcriptionally active chromatin (Métivier et al, 2003. CARM1 is an alternate arginine methyltransferase with activity toward H3 R17 that acts at the TFF enhancer, however CARM1 and PRMT1 are never found simultaneously at the TFF1 gene (Métivier et al, 2003; reviewed in Xu et al, 2003; Arnal et al, 2017).Note that in this diagram, methylation of H4 R3 is not depicted.

Literature References

PubMed ID	Title	Journal	Year
28539435	Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications Arnal, JF, Lenfant, F, Métivier, R, Flouriot, G, Henrion, D, Adlanmerini, M, Fontaine, C, Gourdy, P, Chambon, P, Katzenellenbogen, B, Katzenellenbogen, J	Physiol. Rev.	2017
14675539	Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter Métivier, R, Penot, G, Hübner, MR, Reid, G, Brand, H, Kos, M, Gannon, F	Cell	2003
14631847	Acetylation and methylation in nuclear receptor gene activation Xu, W, Cho, H, Evans, RM	Meth. Enzymol.	2003