Estrogen-responsive TFF1 gene expression

Stable Identifier
Reaction [omitted]
Homo sapiens
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Estrogen-dependent TFF1 expression is promoted by the formation of FOXA1- and GATA3-dependent chromatin loops. (Laganière et al, 2005; Theodorou et al, 2013; reviewed in Zaret and Carroll, 2011).Interaction of ligand-bound ESR1 with the enhancer promotes recruitment of histone acetyltransferases and methyltransferases, which establish transcriptionally active chromatin structures and facilitate recruitment of RNA polymerase II (Métivier et al, 2003; reviewed in Xu et al, 2003, Arnal et al, 2017).
Literature References
PubMed ID Title Journal Year
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Katzenellenbogen, B, Chambon, P, Flouriot, G, Métivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M

Physiol. Rev. 2017
16087863 From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response

Bataille, AR, Giguère, V, Robert, F, Lefebvre, C, Laganière, J, Deblois, G

Proc. Natl. Acad. Sci. U.S.A. 2005
22056668 Pioneer transcription factors: establishing competence for gene expression

Zaret, KS, Carroll, JS

Genes Dev. 2011
23172872 GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

Stark, R, Menon, S, Carroll, JS, Theodorou, V

Genome Res. 2013
14675539 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Hübner, MR

Cell 2003
14631847 Acetylation and methylation in nuclear receptor gene activation

Xu, W, Evans, RM, Cho, H

Meth. Enzymol. 2003
16009131 Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1

Szary, AJ, Shao, W, Li, W, Geistlinger, TR, Liu, XS, Hestermann, EV, Meyer, CA, Brodsky, AS, Silver, PA, Fox, EA, Brown, M, Eeckhoute, J, Carroll, JS

Cell 2005
This event is regulated
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