Cathepsin D (CTSD) is a lysosomal aspartyl protease that plays a role in the protein processing and degradation. In addition to its 'housekeeping' roles, CTSD controls the processing of proteins involved in cell cycle progression, differentiation, migration, immunology, neurogenesis, apoptosis and angiogenesis (reviewed in Zaidi et al, 2008; Khalkhali-Ellis and Hendrix, 2015). CTSD is overexpressed in many breast cancers and is implicated in tumor progression and metastasis (Fusek and Vetvicka, 2005). CTSD expression is constitutive in ESR1-negative cells, but estrogen-dependent in ESR1-positive cells (Liaudet-Coopman et al, 2006). Estrogen-responsiveness is conferred by imperfect EREs in both the proximal and the distal promoter and is facilitated by ESR1-dependent looping of the enhancer (Cavaillès et al, 1993; Augereau et al, 1994; Shang et al, 2004; Bourdeau et al, 2004; Bretschneider et al, 2008)
Khalkhali-Ellis, Z, Hendrix, MJ
Shang, Y, Hu, X, DiRenzo, J, Lazar, MA, Brown, M
Zaidi, N, Maurer, A, Nieke, S, Kalbacher, H
Augereau, P, Miralles, F, Cavaillès, V, Gaudelet, C, Parker, M, Rochefort, H
Bourdeau, V, Deschênes, J, Métivier, R, Nagai, Y, Nguyen, D, Bretschneider, N, Gannon, F, White, JH, Mader, S
Bretschneider, N, Kangaspeska, S, Seifert, M, Reid, G, Gannon, F, Denger, S
Cavaillès, V, Augereau, P, Rochefort, H
Liaudet-Coopman, E, Beaujouin, M, Derocq, D, Garcia, M, Glondu-Lassis, M, Laurent-Matha, V, Prébois, C, Rochefort, H, Vignon, F
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