Estrogen-responsive CTSD expression

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cathepsin D (CTSD) is a lysosomal aspartyl protease that plays a role in the protein processing and degradation. In addition to its 'housekeeping' roles, CTSD controls the processing of proteins involved in cell cycle progression, differentiation, migration, immunology, neurogenesis, apoptosis and angiogenesis (reviewed in Zaidi et al, 2008; Khalkhali-Ellis and Hendrix, 2015). CTSD is overexpressed in many breast cancers and is implicated in tumor progression and metastasis (Fusek and Vetvicka, 2005). CTSD expression is constitutive in ESR1-negative cells, but estrogen-dependent in ESR1-positive cells (Liaudet-Coopman et al, 2006). Estrogen-responsiveness is conferred by imperfect EREs in both the proximal and the distal promoter and is facilitated by ESR1-dependent looping of the enhancer (Cavaillès et al, 1993; Augereau et al, 1994; Shang et al, 2004; Bourdeau et al, 2004; Bretschneider et al, 2008)
Literature References
PubMed ID Title Journal Year
11136970 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

Hu, X, Brown, M, DiRenzo, J, Shang, Y, Lazar, MA

Cell 2000
25663755 Two Faces of Cathepsin D: Physiological Guardian Angel and Pathological Demon

Khalkhali-Ellis, Z, Hendrix, MJ

Biol Med (Aligarh) 2014
18762174 Cathepsin D: a cellular roadmap

Kalbacher, H, Zaidi, N, Nieke, S, Maurer, A

Biochem. Biophys. Res. Commun. 2008
7935485 Characterization of the proximal estrogen-responsive element of human cathepsin D gene

Miralles, F, Gaudelet, C, Augereau, P, Rochefort, H, Cavaillès, V, Parker, M

Mol. Endocrinol. 1994
15001666 Genome-wide identification of high-affinity estrogen response elements in human and mouse

Deschênes, J, Métivier, R, Nguyen, D, Bretschneider, N, Nagai, Y, Gannon, F, White, JH, Bourdeau, V, Mader, S

Mol. Endocrinol. 2004
19383337 E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements

Reid, G, Kangaspeska, S, Bretschneider, N, Seifert, M, Gannon, F, Denger, S

Mol Oncol 2008
8419924 Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells

Augereau, P, Rochefort, H, Cavaillès, V

Proc. Natl. Acad. Sci. U.S.A. 1993
16046058 Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis

Vignon, F, Prébois, C, Garcia, M, Rochefort, H, Derocq, D, Glondu-Lassis, M, Laurent-Matha, V, Liaudet-Coopman, E, Beaujouin, M

Cancer Lett. 2006
This event is regulated
Cite Us!