Reactome | Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin

Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin

Stable Identifier

R-HSA-9023619

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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General

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Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin

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The majority of circulating ghrelin is not acylated (des-acyl ghrelin). Acyl ghrelin can be deacylated in the bloodstream by butyrylcholinesterase and platelet-activating factor acetylhydrolase, which are associated with circulating lipids. Other enzymes may also have this capability. It is unknown if a portion of des-acyl ghrelin in the bloodstream is generated by direct synthesis and secretion.

Literature References

PubMed ID	Title	Journal	Year
19280057	Ghrelin fluctuation, what determines its production? Yin, X, Li, Y, Zhang, W, An, W, Xu, G	Acta Biochim Biophys Sin (Shanghai)	2009
17289852	Ghrelin interacts with human plasma lipoproteins Carpentier, Y, Delporte, C, Hacquebard, M, De Vriese, C, Gregoire, F	Endocrinology	2007
18396350	Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle Soares, JB, Leite-Moreira, AF	Peptides	2008