The majority of circulating ghrelin is not acylated (des-acyl ghrelin). Acyl ghrelin can be deacylated in the bloodstream by butyrylcholinesterase and platelet-activating factor acetylhydrolase, which are associated with circulating lipids. Other enzymes may also have this capability. It is unknown if a portion of des-acyl ghrelin in the bloodstream is generated by direct synthesis and secretion.
De Vriese, C, Hacquebard, M, Gregoire, F, Carpentier, Y, Delporte, C
Yin, X, Li, Y, Xu, G, An, W, Zhang, W
Soares, JB, Leite-Moreira, AF
hydrolase activity, acting on ester bonds of PLA2G7 [extracellular region]
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