The majority of circulating ghrelin is not acylated (des-acyl ghrelin). Acyl ghrelin can be deacylated in the bloodstream by butyrylcholinesterase and platelet-activating factor acetylhydrolase, which are associated with circulating lipids. Other enzymes may also have this capability. It is unknown if a portion of des-acyl ghrelin in the bloodstream is generated by direct synthesis and secretion.
Yin, X, Li, Y, Zhang, W, An, W, Xu, G
Carpentier, Y, Delporte, C, Hacquebard, M, De Vriese, C, Gregoire, F
Soares, JB, Leite-Moreira, AF
hydrolase activity, acting on ester bonds of PLA2G7 [extracellular region]
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