NOTCH1 gene expression is inhibited by MECP2

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R-HSA-9023345
Type
Reaction [omitted]
Species
Homo sapiens
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Based on studies in mice, increased MECP2 occupancy of the NOTCH1 gene promoter, correlates with decreased transcription of NOTCH1. MECP2 therefore inhibits NOTCH1 transcription. Increased occupancy of the NOTCH1 promoter by MECP2 also results in decreased expression of NOTCH targets HES3 and HES5 (Li et al. 2014).

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