Insulin secretory granule docks at the plasma membrane

Stable Identifier
R-HSA-9023173
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Docking of secretory granules containing insulin occurs by interaction between EXOC3/Sec6 located on the membrane of the secretory granule and EXOC4/Sec8 located at the plasma membrane. Additional components (EXOC1, EXOC2, EXOC5, EXOC6, EXOC7, EXOC8) form the Exocyst Complex. A beta cell contains about 10 000 secretory granules. Of these, about 1000 are docked at the inner surface of the plasma membrane and a subset of about 100 docked granules form the "readily releasable" pool (granules which are released within about 5 minutes of glucose stimulation).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SNARE binding activity of Core SNARE Complex [plasma membrane]
Physical Entity
Activity
This event is regulated
Inferred From
Authored
Reviewed
Created