MECP2 binds 5mC-DNA

Stable Identifier
R-HSA-9022456
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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MECP2 binds 5mC-DNA
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MECP2 binds to DNA containing 5-methylcytosine (5mC-DNA), a DNA modification associated with transcriptional repression (Mellen et al. 2012). MECP2 binds to 5-methyl cytosine both in the context of CpG islands and outside of CpG islands (Chen et al. 2015).

Literature References
PubMed ID Title Journal Year
25870282 MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

Chen, L, Chen, K, Lavery, LA, Baker, SA, Shaw, CA, Li, W, Zoghbi, HY

Proc. Natl. Acad. Sci. U.S.A. 2015
23260135 MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system

Mellén, M, Ayata, P, Dewell, S, Kriaucionis, S, Heintz, N

Cell 2012
Participants
Input
Output
Participant Of
hasEvent
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-22)