MECP2 binds to DNA containing 5-methylcytosine (5mC-DNA), a DNA modification associated with transcriptional repression (Mellen et al. 2012). MECP2 binds to 5-methyl cytosine both in the context of CpG islands and outside of CpG islands (Chen et al. 2015).
Dewell, S, Heintz, N, Mellén, M, Kriaucionis, S, Ayata, P
Chen, K, Li, W, Zoghbi, HY, Lavery, LA, Chen, L, Shaw, CA, Baker, SA
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