MECP2:SIN3A complex binds GRIA2 gene promoter

Stable Identifier
R-HSA-9022359
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Based on studies in rat neurons, neuronal activity induces binding of the MECP2, in complex with SIN3A and HDAC1, to the promoter of the GRIA2 (GLUR2) gene, encoding glutamate receptor 2. Prior phosphorylation of MECP2 on serine residue S423 (corresponding to mouse and rat S421), triggered by neuronal activity, may be required (Qiu et al. 2012).

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