SLC2A3 gene expression is stimulated by MECP2:CREB1 complex

Stable Identifier
R-HSA-9022186
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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SLC2A3 gene expression is stimulated by MECP2:CREB1 complex
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Based on studies in mice, transcription of the SLC2A3 (GLUT3) gene, encoding solute carrier family 2, facilitated glucose transporter member 3, is directly stimulated by the complex of MECP2 and CREB1. In the mouse brain, expression of the Slc2a3 gene is developmentally regulated, peaking at postnatal day 14, which correlates with hypermethylation of the 5' flanking region CpG island (Chen et al. 2013).
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Input
Output
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as an event of
This event is regulated
Positively by
Regulator
MECP2:p-S133-CREB1:SLC2A3 gene [nucleoplasm] (Homo sapiens)
Active Unit
MECP2:p-S133-CREB1 [nucleoplasm]
Inferred From
Slc2a3 gene expression is stimulated by Mecp2:Creb1 complex (Mus musculus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-21)
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