EPOR-associated PI3K phosphorylates PIP2 to PIP3

Stable Identifier
Reaction [transition]
Homo sapiens
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Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) associated with EPOR phosphorylates phosphatidylinositol 4,5-bisphosphate to yield phosphatidyl 3,4,5-trisphosphate (Kubota et al. 2001, Schmidt et al. 2004). PI3K binds the phosphorylated EPOR directly or indirectly via phosphorylated IRS2 or phosphorylated GAB1 (Bouscary et al. 2003).

Literature References
PubMed ID Title Journal Year
11598010 Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase

Kubota, Y, Tanaka, T, Kitanaka, A, Ohnishi, H, Okutani, Y, Waki, M, Ishida, T, Kamano, H

EMBO J. 2001
12506011 Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation

Bouscary, D, Pene, F, Claessens, YE, Muller, O, Chr├ętien, S, Fontenay-Roupie, M, Gisselbrecht, S, Mayeux, P, Lacombe, C

Blood 2003
15149544 PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors

Schmidt, EK, Fichelson, S, Feller, SM

BMC Biol. 2004
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K bound to EPOR [plasma membrane]

Orthologous Events
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