Reactome | ESR-associated SRC autophosphorylates

ESR-associated SRC autophosphorylates

Stable Identifier

R-HSA-9021609

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Estrogen treatment stimulates autophosphorylation of SRC at tyrosine 419 (Haynes et al, 2003). SRC catalytic activity is required for signaling to PI3K, AKT and eNOS, as both a kinase dead version of SRC and treatment of cells with a SRC inhibitor abrogate phosphorylation of these downstream targets. SRC interacts with the p85 regulatory subunit of PI3K and in this way promotes assembly of an estrogen-responsive signaling complex in the caveolae (Simoncini et al, 2000; Hayes et al, 2003; Castoria et al, 2001; Castoria et al, 2012; Le Romancer et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
22266855	Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells Castoria, G, Giovannelli, P, Lombardi, M, De Rosa, C, Giraldi, T, de Falco, A, Barone, MV, Abbondanza, C, Migliaccio, A, Auricchio, F	Oncogene	2012
11029009	Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase Simoncini, T, Hafezi-Moghadam, A, Brazil, DP, Ley, K, Chin, WW, Liao, JK	Nature	2000
12431978	Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen Haynes, MP, Li, L, Sinha, D, Russell, KS, Hisamoto, K, Baron, R, Collinge, M, Sessa, WC, Bender, JR	J. Biol. Chem.	2003
18657504	Regulation of estrogen rapid signaling through arginine methylation by PRMT1 Le Romancer, M, Treilleux, I, Leconte, N, Robin-Lespinasse, Y, Sentis, S, Bouchekioua-Bouzaghou, K, Goddard, S, Gobert-Gosse, S, Corbo, L	Mol. Cell	2008
11689445	PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells Castoria, G, Migliaccio, A, Bilancio, A, Di Domenico, M, de Falco, A, Lombardi, M, Fiorentino, R, Varricchio, L, Barone, MV, Auricchio, F	EMBO J.	2001