ESR-associated SRC autophosphorylates

Stable Identifier
Reaction [transition]
Homo sapiens
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Estrogen treatment stimulates autophosphorylation of SRC at tyrosine 419 (Haynes et al, 2003). SRC catalytic activity is required for signaling to PI3K, AKT and eNOS, as both a kinase dead version of SRC and treatment of cells with a SRC inhibitor abrogate phosphorylation of these downstream targets. SRC interacts with the p85 regulatory subunit of PI3K and in this way promotes assembly of an estrogen-responsive signaling complex in the caveolae (Simoncini et al, 2000; Hayes et al, 2003; Castoria et al, 2001; Castoria et al, 2012; Le Romancer et al, 2008).

Literature References
PubMed ID Title Journal Year
22266855 Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells

Auricchio, F, Migliaccio, A, Castoria, G, De Rosa, C, Barone, MV, de Falco, A, Giraldi, T, Abbondanza, C, Giovannelli, P, Lombardi, M

Oncogene 2012
11029009 Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

Liao, JK, Brazil, DP, Ley, K, Hafezi-Moghadam, A, Simoncini, T, Chin, WW

Nature 2000
12431978 Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen

Baron, R, Haynes, MP, Collinge, M, Li, L, Sessa, WC, Hisamoto, K, Bender, JR, Russell, KS, Sinha, D

J. Biol. Chem. 2003
18657504 Regulation of estrogen rapid signaling through arginine methylation by PRMT1

Leconte, N, Robin-Lespinasse, Y, Gobert-Gosse, S, Bouchekioua-Bouzaghou, K, Goddard, S, Corbo, L, Sentis, S, Treilleux, I, Le Romancer, M

Mol. Cell 2008
11689445 PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

Auricchio, F, Fiorentino, R, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L

EMBO J. 2001
Catalyst Activity

protein tyrosine kinase activity of ESRs:STRN:ESTG:MyrG-SRC [plasma membrane]

Orthologous Events
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