WWC1 (Kibra) gene expression is stimulated by NOTCH3

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R-HSA-9021478
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Reaction [omitted]
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Homo sapiens
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The NOTCH3 coactivator complex directly stimulates WWC1 gene transcription. WWC1 gene encodes the protein Kibra, involved in Hippo signaling. NOTCH3-mediated induction of WWC1 positively regulates Hippo signaling and inhibits epithelial-to-mesenchymal transition (EMT) in triple negative breast cancer cells (Zhang et al. 2016).

Literature References
PubMed ID Title Journal Year
27841855 Notch3 inhibits epithelial-mesenchymal transition by activating Kibra-mediated Hippo/YAP signaling in breast cancer epithelial cells

Zhang, X, Liu, X, Luo, J, Xiao, W, Ye, X, Chen, M, Li, Y, Zhang, GJ

Oncogenesis 2016
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