NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter

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R-HSA-9021451
Type
Reaction [binding]
Species
Homo sapiens
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PLXND1 gene promoter possesses an RBPJ-binding site which is necessary for NOTCH1 and NOTCH3-mediated induction of PLXND1 transcription. It is therefore concluded that NOTCH1 and NOTCH3 co-activator complexes directly bind to the PLXND1 gene promoter (Rehman et al. 2016).

Literature References
PubMed ID Title Journal Year
27749937 PlexinD1 Is a Novel Transcriptional Target and Effector of Notch Signaling in Cancer Cells

Rehman, M, Gurrapu, S, Cagnoni, G, Capparuccia, L, Tamagnone, L

PLoS ONE 2016
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