MECP2 mRNA binds miR-132 RISC

Stable Identifier
R-HSA-9021182
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MicroRNA miR-132 is complementary to the 3'UTR of long MECP2 transcripts (>10 kb), which are predominantly expressed in the brain. Based on studies in mice and rats, miR-132 reduces both mRNA and protein levels of MECP2 and was confirmed to be specific for MECP2 mRNA by the 3'UTR-luciferase reporter gene assay (Klein et al. 2007, Su et al. 2015).

miR-132 levels increase in response to BDNF signaling in a CREB-dependent way (Vo et al. 2005, Klein et al. 2007, Lyu et al. 2016). In patients with major depressive disorder, miR-132 levels are increased while MECP2 and BDNF levels are decreased (Su et al. 2015).

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