Plasma membrane-localized estrogen receptors signal as dimers, and dimerization is promoted by stimulation with estrogen (Razandi et al, 2004). Because palmitoylation of cytoplasmic estrogen receptors occurs on the monomeric form, estrogen (ESTG) stimulation restricts both the amount of palmitoylated receptor and its localization at the plasma membrane (Acconcia et al, 2005; Razandi et al, 2010; Pedram et al, 2012). This may serve to limit the extent of the rapid response to estrogen stimulation.
Levin, ER, Razandi, M, Deschenes, RJ, Pedram, A
Marino, M, Bocedi, A, Trentalance, A, Ascenzi, P, Acconcia, F, Visca, P, Tomasi, V, Spisni, E
Levin, ER, Merchenthaler, I, Razandi, M, Greene, GL, Pedram, A
Levin, ER, Razandi, M, Pedram, A
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