Palmitoylation of estrogen receptors promotes their interaction with caveolin (CAV), which is required for their translocation to the plasma membrane where they function in rapid, transcription-independent signaling (Chambliss et al, 2002; Razandi et al, 2003; Acconcia et al, 2004; Pedram et al, 2007; Razandi et al, 2010; Pedram et al, 2012; reviewed in Schwartz et al, 2016). Approximately 5-15% of total cellular estrogen receptor is at the plasma membrane where it is enriched in caveolae (Pedram et al, 2006; Marino et al, 2006).
Kim, JK, Hughes, CC, Levin, ER, Razandi, M, Sainson, RC, Pedram, A
Levin, ER, Razandi, M, Deschenes, RJ, Pedram, A
Verma, A, Schwartz, Z, Bivens, CB, Schwartz, N, Boyan, BD
Webb, P, Alton, G, Levin, ER, Razandi, M, Ghonshani, S, Pedram, A
Marino, M, Ascenzi, P, Acconcia, F
Mendelsohn, ME, Yuhanna, IS, Chambliss, KL, Shaul, PW, Anderson, RG
Levin, ER, Razandi, M, Pedram, A
Marino, M, Fabozzi, G, Ascenzi, P, Acconcia, F, Visca, P
© 2021 Reactome
