Palmitoylation of estrogen receptors promotes their interaction with caveolin (CAV), which is required for their translocation to the plasma membrane where they function in rapid, transcription-independent signaling (Chambliss et al, 2002; Razandi et al, 2003; Acconcia et al, 2004; Pedram et al, 2007; Razandi et al, 2010; Pedram et al, 2012; reviewed in Schwartz et al, 2016). Approximately 5-15% of total cellular estrogen receptor is at the plasma membrane where it is enriched in caveolae (Pedram et al, 2006; Marino et al, 2006).
Acconcia, F, Ascenzi, P, Fabozzi, G, Visca, P, Marino, M
Chambliss, KL, Yuhanna, IS, Anderson, RG, Mendelsohn, ME, Shaul, PW
Razandi, M, Alton, G, Pedram, A, Ghonshani, S, Webb, P, Levin, ER
Pedram, A, Razandi, M, Sainson, RC, Kim, JK, Hughes, CC, Levin, ER
Marino, M, Ascenzi, P, Acconcia, F
Pedram, A, Razandi, M, Deschenes, RJ, Levin, ER
Pedram, A, Razandi, M, Levin, ER
Razandi, M, Pedram, A, Levin, ER
Schwartz, N, Verma, A, Bivens, CB, Schwartz, Z, Boyan, BD
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