ZDHHC7, ZDHHC21 palmitoylate ESR1

Stable Identifier
Reaction [transition]
Homo sapiens
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In addition to nuclear signaling, estrogen receptors also promote a rapid, transcription- and translation-independent signaling response from the plasma membrane (reviewed in Levin, 2005; Schwartz et al, 2016). In contrast to their classical nuclear counterparts, estrogen receptors that signal from the plasma membrane are lipid-modified by palmitoylation. The amino-acid sequence encompassing an exposed cysteine residue (Cys447 for ESR1 and Cys399 for ESR2) is conserved between other steroid hormone receptors (Marino and Ascenzi, 2006). Mutation of the target cysteine in this motif abrogates membrane localization and the rapid response to estrogen (Acconcia et al, 2004; Acconcia et al, 2005; Pedram et al, 2007; Pedram et al, 2011). Golgi-localized palmitoyltransferases ZDHHC7 and ZDHHC21 catalyze the transfer of palmitoyl to the cysteine residue in the estrogen receptor (Pedram et al, 2012).

Literature References
PubMed ID Title Journal Year
17424910 Steroid hormone rapid signaling: the pivotal role of S-palmitoylation

Marino, M, Ascenzi, P

IUBMB Life 2006
15033483 S-palmitoylation modulates human estrogen receptor-alpha functions

Marino, M, Fabozzi, G, Ascenzi, P, Acconcia, F, Visca, P

Biochem. Biophys. Res. Commun. 2004
17535799 A conserved mechanism for steroid receptor translocation to the plasma membrane

Kim, JK, Hughes, CC, Levin, ER, Razandi, M, Sainson, RC, Pedram, A

J. Biol. Chem. 2007
22031296 DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors

Levin, ER, Razandi, M, Deschenes, RJ, Pedram, A

Mol. Biol. Cell 2012
25587652 Extranuclear steroid receptors are essential for steroid hormone actions

Levin, ER

Annu. Rev. Med. 2015
15496458 Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol

Marino, M, Bocedi, A, Trentalance, A, Ascenzi, P, Acconcia, F, Visca, P, Tomasi, V, Spisni, E

Mol. Biol. Cell 2005
27288742 Rapid steroid hormone actions via membrane receptors

Verma, A, Schwartz, Z, Bivens, CB, Schwartz, N, Boyan, BD

Biochim. Biophys. Acta 2016
Catalyst Activity

protein-cysteine S-palmitoyltransferase activity of ZDHHC7, ZDHHC21 [Golgi membrane]

Orthologous Events
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