PalmS-ESRs bind CAVs

Stable Identifier
Reaction [binding]
Homo sapiens
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Palmitoylated estrogen receptors bind caveolin proteins (CAVs) prior to translocation to the plasma membrane (Razandi et al, 2002; Acconcia et al, 2004; Acconcia et al, 2005; Pedram et al, 2007; Pedram et al, 2012). Membrane localization depends on the scaffolding domain (aa 80- 100) of caveolin, although this region is dispensable for estrogen receptor binding (Razandi et al, 2002; Pedram et al, 2007). Interaction between caveolin and the estrogen receptor is diminished upon stimulation of cells with E2 (beta-estradiol) in some cell types, which may restrict the duration of the immediate signaling (Acconcia et al, 2004; Acconcia et al, 2005).

Literature References
PubMed ID Title Journal Year
15033483 S-palmitoylation modulates human estrogen receptor-alpha functions

Marino, M, Fabozzi, G, Ascenzi, P, Acconcia, F, Visca, P

Biochem. Biophys. Res. Commun. 2004
17535799 A conserved mechanism for steroid receptor translocation to the plasma membrane

Kim, JK, Hughes, CC, Levin, ER, Razandi, M, Sainson, RC, Pedram, A

J. Biol. Chem. 2007
22031296 DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors

Levin, ER, Razandi, M, Deschenes, RJ, Pedram, A

Mol. Biol. Cell 2012
11773442 ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions

Levin, ER, Razandi, M, Oh, P, Schnitzer, J, Pedram, A

Mol. Endocrinol. 2002
15496458 Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol

Marino, M, Bocedi, A, Trentalance, A, Ascenzi, P, Acconcia, F, Visca, P, Tomasi, V, Spisni, E

Mol. Biol. Cell 2005
Orthologous Events
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