Reactome | PalmS-ESRs bind CAVs

PalmS-ESRs bind CAVs

Stable Identifier

R-HSA-9021068

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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Palmitoylated estrogen receptors bind caveolin proteins (CAVs) prior to translocation to the plasma membrane (Razandi et al, 2002; Acconcia et al, 2004; Acconcia et al, 2005; Pedram et al, 2007; Pedram et al, 2012). Membrane localization depends on the scaffolding domain (aa 80- 100) of caveolin, although this region is dispensable for estrogen receptor binding (Razandi et al, 2002; Pedram et al, 2007). Interaction between caveolin and the estrogen receptor is diminished upon stimulation of cells with E2 (beta-estradiol) in some cell types, which may restrict the duration of the immediate signaling (Acconcia et al, 2004; Acconcia et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
15033483	S-palmitoylation modulates human estrogen receptor-alpha functions Marino, M, Fabozzi, G, Ascenzi, P, Acconcia, F, Visca, P	Biochem. Biophys. Res. Commun.	2004
17535799	A conserved mechanism for steroid receptor translocation to the plasma membrane Kim, JK, Hughes, CC, Levin, ER, Razandi, M, Sainson, RC, Pedram, A	J. Biol. Chem.	2007
22031296	DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors Levin, ER, Razandi, M, Deschenes, RJ, Pedram, A	Mol. Biol. Cell	2012
11773442	ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions Levin, ER, Razandi, M, Oh, P, Schnitzer, J, Pedram, A	Mol. Endocrinol.	2002
15496458	Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol Marino, M, Bocedi, A, Trentalance, A, Ascenzi, P, Acconcia, F, Visca, P, Tomasi, V, Spisni, E	Mol. Biol. Cell	2005