PalmS-ESRs bind CAVs

Stable Identifier
R-HSA-9021068
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Palmitoylated estrogen receptors bind caveolin proteins (CAVs) prior to translocation to the plasma membrane (Razandi et al, 2002; Acconcia et al, 2004; Acconcia et al, 2005; Pedram et al, 2007; Pedram et al, 2012). Membrane localization depends on the scaffolding domain (aa 80- 100) of caveolin, although this region is dispensable for estrogen receptor binding (Razandi et al, 2002; Pedram et al, 2007). Interaction between caveolin and the estrogen receptor is diminished upon stimulation of cells with E2 (beta-estradiol) in some cell types, which may restrict the duration of the immediate signaling (Acconcia et al, 2004; Acconcia et al, 2005).

Literature References
PubMed ID Title Journal Year
17535799 A conserved mechanism for steroid receptor translocation to the plasma membrane

Pedram, A, Razandi, M, Sainson, RC, Kim, JK, Hughes, CC, Levin, ER

J. Biol. Chem. 2007
15033483 S-palmitoylation modulates human estrogen receptor-alpha functions

Acconcia, F, Ascenzi, P, Fabozzi, G, Visca, P, Marino, M

Biochem. Biophys. Res. Commun. 2004
22031296 DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors

Pedram, A, Razandi, M, Deschenes, RJ, Levin, ER

Mol. Biol. Cell 2012
11773442 ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions

Razandi, M, Oh, P, Pedram, A, Schnitzer, J, Levin, ER

Mol. Endocrinol. 2002
15496458 Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol

Acconcia, F, Ascenzi, P, Bocedi, A, Spisni, E, Tomasi, V, Trentalance, A, Visca, P, Marino, M

Mol. Biol. Cell 2005
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