Reactome | HSBP1 oligomer binds ESRs

HSBP1 oligomer binds ESRs

Stable Identifier

R-HSA-9021050

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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HSBP1 (also known as HSP27) binds to exposed cysteine residues of ESR1 to promote its palmitoylation (Acconcia et al, 2005; Razandi et al, 2010). HSBP1 binds to monomeric estrogen receptor and is predicted to promote a conformational change that allows the palmitoylacyltransferases ZDHHC7 and ZDHHC21 access to the target cysteine residue (Razandi et al, 2010; Pedram et al, 2012). Palmitoylation is required for association of the estrogen receptor with caveolin, which in turn promotes membrane localization and activity (Acconcia et al, 2004; Acconcia et al, 2005; Pedram et al, 2007; Pedram et al, 2012; reviewed in Schwartz et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
15033483	S-palmitoylation modulates human estrogen receptor-alpha functions Marino, M, Fabozzi, G, Ascenzi, P, Acconcia, F, Visca, P	Biochem. Biophys. Res. Commun.	2004
17535799	A conserved mechanism for steroid receptor translocation to the plasma membrane Kim, JK, Hughes, CC, Levin, ER, Razandi, M, Sainson, RC, Pedram, A	J. Biol. Chem.	2007
22031296	DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors Levin, ER, Razandi, M, Deschenes, RJ, Pedram, A	Mol. Biol. Cell	2012
20439495	Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane Levin, ER, Razandi, M, Pedram, A	Mol. Cell. Biol.	2010
15496458	Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol Marino, M, Bocedi, A, Trentalance, A, Ascenzi, P, Acconcia, F, Visca, P, Tomasi, V, Spisni, E	Mol. Biol. Cell	2005
27288742	Rapid steroid hormone actions via membrane receptors Verma, A, Schwartz, Z, Bivens, CB, Schwartz, N, Boyan, BD	Biochim. Biophys. Acta	2016