GRIN2B gene expression is inhibited by MECP2

Stable Identifier
R-HSA-9020513
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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GRIN2B gene expression is inhibited by MECP2
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Based on the study in rats, transcription of the GRIN2B (NR2B) gene, encoding glutamate (NMDA) receptor subunit epsilon-2, is inhibited by promoter methylation and subsequent MECP2 binding. GRIN2B promoter methylation and MECP2 binding are stimulated by neuronal activity. Suppression of neuronal activity leads to demethylation of the GRIN2B promoter and increased GRIN2B transcription (Lee et al. 2008).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2:GRIN2B gene [nucleoplasm] (Homo sapiens)
Active Unit
MECP2 [nucleoplasm]
Inferred From
Grin2b gene expression is inhibited by Mecp2 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-06)
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