MECP2 binds GRIN2B gene promoter

Stable Identifier
R-HSA-9020504
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on study in rats, MECP2 binds to methylated GRIN2B (NR2B) gene promoter, encoding glutamate (NMDA) receptor subunit epsilon-2. Methylation of the GRIN2B promoter and the subsequent MECP2 binding is promoted by increased neuronal activity and suppressed by low neuronal activity (Lee et al. 2008).

Participants
Participant Of
Inferred From
Authored
Reviewed
Created
Cite Us!