MECP2 binds GRIN2B gene promoter

Stable Identifier
R-HSA-9020504
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MECP2 binds GRIN2B gene promoter
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Based on study in rats, MECP2 binds to methylated GRIN2B (NR2B) gene promoter, encoding glutamate (NMDA) receptor subunit epsilon-2. Methylation of the GRIN2B promoter and the subsequent MECP2 binding is promoted by increased neuronal activity and suppressed by low neuronal activity (Lee et al. 2008).
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Mecp2 binds to Grin2b gene promoter (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-06)
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