Reactome | ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA

ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA

Stable Identifier

R-HSA-9020278

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA

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5-lipoxygenase (ALOX5) possesses dual lipoxygenase activity (Shimizu et al. 1984). In polymorphonuclear (PMN) cells, ALOX5 can epoxygenate (via dehydration) 4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid (4(S)-Hp-17(R)-HDHA) to form 4S(5)-epoxy-17(R)-hydroxydocosahexaenoic acid (4S(5)-epoxy-17(R)-HDHA (Serhan et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12391014	Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals Gronert, K, Serhan, CN, Devchand, PR, Colgan, SP, Hong, S, Mirick, G, Moussignac, RL	J. Exp. Med.	2002