Reactome | GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA

GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA

Stable Identifier

R-HSA-9020271

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA

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Cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 17(R)-hydroperoxy-docosahexaenoic acid (17(R)-Hp-DHA) to 17(R)-hydroxydocosahexaenoic acid (17(R)-HDHA) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013). 17(R)-HDHA can then be transformed into 17(R)-D-resolvins and a 17-oxo electrophilic product 17-oxo-DHA (Groeger et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
24170573	Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase Han, X, Fan, Z, Yu, Y, Liu, S, Hao, Y, Huo, R, Wei, J	IUBMB Life	2013
8605014	Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury Yagi, K, Komura, S, Kojima, H, Sun, Q, Nagata, N, Ohishi, N, Nishikimi, M	Biochem. Biophys. Res. Commun.	1996