Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 4S(5)-epoxy-17(R)-hydroxydocosahexaenoic acid (4S(5)-epoxy-17(R)-HDHA) to the trihydroxydocosahexaenoic acids 4(S), 11(R), 17(R)-triHDHA and 4(S), 5(R), 17(R)-triHDHA (AT-RvD3 and AT-RvD4 respectively) (Dalli et al. 2013, Serhan et al. 2002, Winkler et al. 2013, 2016). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).
Serhan, CN, Cheng, CY, Winkler, JW, Sanger, JM, Petasis, NA, Chiang, N, Orr, SK, Dalli, J
Gronert, K, Serhan, CN, Devchand, PR, Colgan, SP, Hong, S, Mirick, G, Moussignac, RL
Colas, RA, Hansen, TV, Tungen, JE, Vik, A, Dalli, J, Primdahl, KG, De Souza, PRS
Serhan, CN, Colas, RA, Cheng, CY, Winkler, JW, Petasis, NA, Chiang, N, Arnardottir, H, Dalli, J
epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]
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