Reactome | LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4

LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4

Stable Identifier

R-HSA-9020270

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4

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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 4S(5)-epoxy-17(R)-hydroxydocosahexaenoic acid (4S(5)-epoxy-17(R)-HDHA) to the trihydroxydocosahexaenoic acids 4(S), 11(R), 17(R)-triHDHA and 4(S), 5(R), 17(R)-triHDHA (AT-RvD3 and AT-RvD4 respectively) (Dalli et al. 2013, Serhan et al. 2002, Winkler et al. 2013, 2016). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
26743932	Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance Serhan, CN, Cheng, CY, Winkler, JW, Sanger, JM, Petasis, NA, Chiang, N, Orr, SK, Dalli, J	Sci Rep	2016
12391014	Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals Gronert, K, Serhan, CN, Devchand, PR, Colgan, SP, Hong, S, Mirick, G, Moussignac, RL	J. Exp. Med.	2002
28980694	Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA Colas, RA, Hansen, TV, Tungen, JE, Vik, A, Dalli, J, Primdahl, KG, De Souza, PRS	Org. Biomol. Chem.	2017
23438748	Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents Serhan, CN, Colas, RA, Cheng, CY, Winkler, JW, Petasis, NA, Chiang, N, Arnardottir, H, Dalli, J	Chem. Biol.	2013