LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4

Stable Identifier
Reaction [transition]
Homo sapiens
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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 4S(5)-epoxy-17(R)-hydroxydocosahexaenoic acid (4S(5)-epoxy-17(R)-HDHA) to the trihydroxydocosahexaenoic acids 4(S), 11(R), 17(R)-triHDHA and 4(S), 5(R), 17(R)-triHDHA (AT-RvD3 and AT-RvD4 respectively) (Dalli et al. 2013, Serhan et al. 2002, Winkler et al. 2013, 2016). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).

Literature References
PubMed ID Title Journal Year
26743932 Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

Serhan, CN, Cheng, CY, Winkler, JW, Sanger, JM, Petasis, NA, Chiang, N, Orr, SK, Dalli, J

Sci Rep 2016
12391014 Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

Gronert, K, Serhan, CN, Devchand, PR, Colgan, SP, Hong, S, Mirick, G, Moussignac, RL

J. Exp. Med. 2002
28980694 Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA

Colas, RA, Hansen, TV, Tungen, JE, Vik, A, Dalli, J, Primdahl, KG, De Souza, PRS

Org. Biomol. Chem. 2017
23438748 Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents

Serhan, CN, Colas, RA, Cheng, CY, Winkler, JW, Petasis, NA, Chiang, N, Arnardottir, H, Dalli, J

Chem. Biol. 2013
Catalyst Activity

epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]

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