ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA

Stable Identifier
R-HSA-9020262
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA
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The hydroperoxide intermediate of docosahexaenoic acid (17(R)-Hp-DHA) undergoes a second hydrogen abstraction by 15-lipoxygenase (ALOX15) to form the intermediate epoxide 17R(16)-epoxy-DHA (Serhan et al. 2011).
Literature References
PubMed ID Title Journal Year
21867913 Novel proresolving aspirin-triggered DHA pathway

Zhu, M, Serhan, CN, Winkler, JW, Petasis, NA, Bazan, NG, Fredman, G, Karamnov, S, Yang, R, Belayev, LS

Chem. Biol. 2011
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Catalyst Activity

arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]

Physical Entity
ALOX15 [cytosol] (Homo sapiens)
Activity
arachidonate 15-lipoxygenase activity (GO:0050473)
Orthologous Events
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Bos taurus)
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Canis familiaris)
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Danio rerio)
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Dictyostelium discoideum)
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Mus musculus)
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Rattus norvegicus)
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Sus scrofa)
Authored
Jassal, B  (2017-09-05)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-09-05)
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