ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA

Stable Identifier
R-HSA-9020251
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Lipoxygenase 5 (ALOX5) can oxidise 17(R)-hydroxydocosahexaenoic acid (17(R)-HDHA) into two hydroperoxy intermediates in human polymorphonuclear leukocytes (PMNs) (Serhan et al. 2002). The formation of 7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid (7(S)-Hp-17(R)-HDHA) is decribed here.

Literature References
PubMed ID Title Journal Year
12391014 Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

Serhan, CN, Hong, S, Gronert, K, Colgan, SP, Devchand, PR, Mirick, G, Moussignac, RL

J. Exp. Med. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 5-lipoxygenase activity of ALOX5 [cytosol]
Physical Entity
Activity
Orthologous Events
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