ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3

Stable Identifier
R-HSA-9018907
Type
Reaction [transition]
Species
Homo sapiens
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Unlike resolvins E1 and E2, both of which are biosynthesised by neutrophils via the 5-lipoxygenase pathway, resolvin E3 (RvE3) is biosynthesised in eosinophils or resident macrophages via the 15-lipoxygenase (ALOX15) pathway. 18(R)-hydroxyeicosapentaenoic acid (18(R)-HEPE) is oxidised by ALOX15 (possibly through C13-hydrogen abstraction) into a number of dihydroxy-HEPEs including 17(R),18(R)-diHEPE (18(R)-RvE3) (Isobe et al. 2012, Isobe et al. 2013).

Literature References
PubMed ID Title Journal Year
22275352 Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid

Isobe, Y, Arita, M, Matsueda, S, Iwamoto, R, Fujihara, T, Nakanishi, H, Taguchi, R, Masuda, K, Sasaki, K, Urabe, D, Inoue, M, Arai, H

J. Biol. Chem. 2012
23293324 Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3

Isobe, Y, Arita, M, Iwamoto, R, Urabe, D, Todoroki, H, Masuda, K, Inoue, M, Arai, H

J. Biochem. 2013
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Catalyst Activity
Title
arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]
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Orthologous Events
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