5-HEDH dehydrogenates 5(S)-Hp-18(R)-HEPE to 18(R)-RvE2

Stable Identifier
R-HSA-9018901
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => A + H2O + resolvin E2
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
5-HEDH dehydrogenates 5(S)-Hp-18(R)-HEPE to 18(R)-RvE2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
An unknown dehydrogenase reduces 5(S)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(R)-HEPE) into the 18(R) stereoisomer of resolvin E2 (18(R)-RvE2). The unknown enzyme may be 5-hydroxyeicosanoid dehydrogenase (5-HEDH) or one similar to this (Patel et al. 2009). Human neutrophils biosynthesise RvE2 in greater amounts than RvE1, suggesting a significant role for RvE2 (Tjonahen et al. 2006, Oh et al. 2012).
Literature References
PubMed ID Title Journal Year
19164464 Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids

Patel, P, Cossette, C, Anumolu, JR, Erlemann, KR, Grant, GE, Rokach, J, Powell, WS

J. Pharmacol. Exp. Ther. 2009
17114001 Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis

Tjonahen, E, Oh, SF, Siegelman, J, Elangovan, S, Percarpio, KB, Hong, S, Arita, M, Serhan, CN

Chem. Biol. 2006
22450811 Resolvin E2 formation and impact in inflammation resolution

Oh, SF, Dona, M, Fredman, G, Krishnamoorthy, S, Irimia, D, Serhan, CN

J. Immunol. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

NADPH dehydrogenase activity of 5-HEDH [cytosol]

Physical Entity
5-HEDH [cytosol] (Homo sapiens)
Activity
NADPH dehydrogenase activity (GO:0003959)
Cross References
RHEA
Authored
Jassal, B  (2017-09-05)
Reviewed
Hansen, TV  (2018-02-21)
Hill, DP  (2024-08-02)
Created
Jassal, B  (2017-09-05)
Cite Us!