5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2

Stable Identifier
R-HSA-9018901
Type
Reaction [transition]
Species
Homo sapiens
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An unknown dehydrogenase reduces 5(S)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(R)-HEPE) into the 18(R) stereoisomer of resolvin E2 (18(R)-RvE2). The unknown enzyme may be 5-hydroxyeicosanoid dehydrogenase (5-HEDH) or one similar to this (Patel et al. 2009). Human neutrophils biosynthesise RvE2 in greater amounts than RvE1, suggesting a significant role for RvE2 (Tjonahen et al. 2006, Oh et al. 2012).

Literature References
PubMed ID Title Journal Year
17114001 Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis

Tjonahen, E, Oh, SF, Siegelman, J, Elangovan, S, Percarpio, KB, Hong, S, Arita, M, Serhan, CN

Chem. Biol. 2006
19164464 Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids

Patel, P, Cossette, C, Anumolu, JR, Erlemann, KR, Grant, GE, Rokach, J, Powell, WS

J. Pharmacol. Exp. Ther. 2009
22450811 Resolvin E2 formation and impact in inflammation resolution

Oh, SF, Dona, M, Fredman, G, Krishnamoorthy, S, Irimia, D, Serhan, CN

J. Immunol. 2012
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Title
NADPH dehydrogenase activity of 5-HEDH [cytosol]
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