5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2

Stable Identifier
Reaction [transition]
Homo sapiens
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An unknown dehydrogenase reduces 5(S)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(R)-HEPE) into the 18(R) stereoisomer of resolvin E2 (18(R)-RvE2). The unknown enzyme may be 5-hydroxyeicosanoid dehydrogenase (5-HEDH) or one similar to this (Patel et al. 2009). Human neutrophils biosynthesise RvE2 in greater amounts than RvE1, suggesting a significant role for RvE2 (Tjonahen et al. 2006, Oh et al. 2012).

Literature References
PubMed ID Title Journal Year
19164464 Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids

Rokach, J, Grant, GE, Patel, P, Erlemann, KR, Cossette, C, Anumolu, JR, Powell, WS

J. Pharmacol. Exp. Ther. 2009
17114001 Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis

Serhan, CN, Arita, M, Percarpio, KB, Oh, SF, Elangovan, S, Hong, S, Tjonahen, E, Siegelman, J

Chem. Biol. 2006
22450811 Resolvin E2 formation and impact in inflammation resolution

Serhan, CN, Dona, M, Krishnamoorthy, S, Irimia, D, Oh, SF, Fredman, G

J. Immunol. 2012
Catalyst Activity

NADPH dehydrogenase activity of 5-HEDH [cytosol]

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