In PMNs, cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 18(R)-HpEPE to 18(R)-hydroxyeicosapentaenoic acid (18(R)-HEPE) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013).
Hao, Y, Fan, Z, Yu, Y, Huo, R, Han, X, Wei, J, Liu, S
Nagata, N, Komura, S, Ohishi, N, Sun, Q, Yagi, K, Nishikimi, M, Kojima, H
phospholipid-hydroperoxide glutathione peroxidase activity of GPX4-2 [cytosol]
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