Reactome | GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE

GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE

Stable Identifier

R-HSA-9018895

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE

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In PMNs, cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 18(R)-HpEPE to 18(R)-hydroxyeicosapentaenoic acid (18(R)-HEPE) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013).

Literature References

PubMed ID	Title	Journal	Year
8605014	Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury Yagi, K, Komura, S, Kojima, H, Sun, Q, Nagata, N, Ohishi, N, Nishikimi, M	Biochem. Biophys. Res. Commun.	1996
24170573	Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase Han, X, Fan, Z, Yu, Y, Liu, S, Hao, Y, Huo, R, Wei, J	IUBMB Life	2013