Reactome | ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE

ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE

Stable Identifier

R-HSA-9018894

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE

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In neutrophils, 5-lipoxygenase (ALOX5) can mediate the insertion of molecular oxygen into 5(S)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(R)-HEPE) to form 5S,6S-epoxy-18(R)-HEPE which is essential for 18(R)-resolvin E1 biosynthesis (Tjonahen et al. 2006, Oh et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
17114001	Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis Tjonahen, E, Oh, SF, Siegelman, J, Elangovan, S, Percarpio, KB, Hong, S, Arita, M, Serhan, CN	Chem. Biol.	2006
22450811	Resolvin E2 formation and impact in inflammation resolution Oh, SF, Dona, M, Fredman, G, Krishnamoorthy, S, Irimia, D, Serhan, CN	J. Immunol.	2012