Reactome | ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE

ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE

Stable Identifier

R-HSA-9018894

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE

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In neutrophils, 5-lipoxygenase (ALOX5) can mediate the insertion of molecular oxygen into 5(S)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(R)-HEPE) to form 5S,6S-epoxy-18(R)-HEPE which is essential for 18(R)-resolvin E1 biosynthesis (Tjonahen et al. 2006, Oh et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
17114001	Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis Serhan, CN, Arita, M, Percarpio, KB, Oh, SF, Elangovan, S, Hong, S, Tjonahen, E, Siegelman, J	Chem. Biol.	2006
22450811	Resolvin E2 formation and impact in inflammation resolution Serhan, CN, Dona, M, Krishnamoorthy, S, Irimia, D, Oh, SF, Fredman, G	J. Immunol.	2012