ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE

Stable Identifier
R-HSA-9018894
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In neutrophils, 5-lipoxygenase (ALOX5) can mediate the insertion of molecular oxygen into 5(S)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(R)-HEPE) to form 5S,6S-epoxy-18(R)-HEPE which is essential for 18(R)-resolvin E1 biosynthesis (Tjonahen et al. 2006, Oh et al. 2012).

Literature References
PubMed ID Title Journal Year
22450811 Resolvin E2 formation and impact in inflammation resolution

Oh, SF, Dona, M, Fredman, G, Krishnamoorthy, S, Irimia, D, Serhan, CN

J. Immunol. 2012
17114001 Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis

Tjonahen, E, Oh, SF, Siegelman, J, Elangovan, S, Percarpio, KB, Hong, S, Arita, M, Serhan, CN

Chem. Biol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 5-lipoxygenase activity of ALOX5 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created