CYP monooxygenates EPA to 18(S)-HpEPE

Stable Identifier
R-HSA-9018874
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The same cytochrome P450 (CYP) isoforms that metabolise the ω-6 polyunsaturated fatty acid (PUFA) arachidonic acid (AA) accept the ω-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as efficient alternative substrates (Arnold et al. 2010a). Several human CYPs are thought to oxidise EPA to 18(S)-hydroperoxyeicosapentaenoic acid (18(S)-HpEPE) although the exact CYP enzymes involved are not known (Arnold et al. 2010b, Weylandt et al. 2012). Microbial CYPs can generate 18-HEPE from EPA (Serhan et al. 2000) that can be converted by human PMNs to RvE1 and RvE2 (Arita et al. 2005). The microbial content in the local environment can therefore, also be a critical factor in the production of E-series resolvins in vivo in humans.

Literature References
PubMed ID Title Journal Year
20732876 Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids

Arnold, C, Markovic, M, Blossey, K, Wallukat, G, Fischer, R, Dechend, R, Konkel, A, von Schacky, C, Luft, FC, Muller, DN, Rothe, M, Schunck, WH

J. Biol. Chem. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP [endoplasmic reticulum membrane]
Physical Entity
Activity
Authored
Reviewed
Created
Cite Us!