Reactome | GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE

GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE

Stable Identifier

R-HSA-9018868

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE

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In PMNs, cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 18(S)-HpEPE to 18(S)-hydroxyeicosapentaenoic acid (18(S)-HEPE) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013).

Literature References

PubMed ID	Title	Journal	Year
24170573	Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase Hao, Y, Fan, Z, Yu, Y, Huo, R, Han, X, Wei, J, Liu, S	IUBMB Life	2013
8605014	Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury Nagata, N, Komura, S, Ohishi, N, Sun, Q, Yagi, K, Nishikimi, M, Kojima, H	Biochem. Biophys. Res. Commun.	1996